Research in the Lung Cancer Out-patient Clinic (LUCA) focuses on improving standards for investigation and treatment of patients with lung cancer  in close collaboration with colleagues from the Department of Oncology and the Department of Radiology at Aarhus University Hospital, and from the Research Unit for General Practice at the Department of Public Health at Aarhus University.

Among current studies are:

A study aiming at optimising the oncological treatment of patients with non-small cell lung cancer (NSCLC) with mutations in the epidermal growth factor receptor (EGFR). Inhibition of EGFR is associated with prolonged survival in some patients with NSCLC and patients with mutations in EGFR are among the responders. But the importance of the expressions of the other members of the EGF system is unknown.  
All patients undergoing investigation for lung cancer are invited  to participate. Participants give blood samples and samples from needle aspirations from the tumour and lymph nodes if such samples are  part of the clinical investigations.

A randomised controlled study aiming at evaluating the diagnostic strategy for patients referred to the lung cancer fast track pathway.
Lung cancer is the most common cause of cancer death in Denmark, and triaging patients through fast track pathways is recommended to improve patient experience and outcome. While such pathways are likely to lead to earlier diagnosis and treatment, data on the most efficient organisation of the pathways is limited.
The randomised intervention consists of a chest CT scan performed before chest physician evaluation. The study outcome is effectiveness as measured by spent physician time per patient, number of CT scans and staff acceptability.

A study evaluating the use of microwave ablation as an alternative local treatment of lung tumours - primary or metastatic - in patients ineligible for surgery. Microwave ablation is a new, careful, and fast treatment which seems to be an effective alternative in local treatment of lung tumours. The ablation is performed as a single treatment in anesthetized patients, where an antenna built in a CT-guided needle is placed in the lung tumour. The antenna will emit electromagnetic impulses for 10 minutes to heat and destroy the tumour. Half of the patients will be discharged from the hospital the following day, the majority of the remaining patients within 2-3 days.

Contacts

Torben Riis Rasmussen, MD, PhD, Consultant, Associate Professor, Specialist in Respiratory Medicine, torbrasm@rm.dk
Birgitte Folkersen, MD, Consultant, Specialist in Respiratory Medicine, birgfolk@rm.dk