Since 1986 we have studied the genetics and epigenetics in hydatidiform moles. We have shown that ploidy is a specific prognostic marker concerning cancer risk and that some moles are mosaics, likely originating in polyploid zygotes.

We are currently studying the mechanism leading to the diploid androgenetic genome in most diploid moles, the role of NLRP genes in hereditary predisposition to moles and other miscarriages, and we exploit hydatidiform moles with aneuploidy for mapping genes regulated by genomic imprinting.
The Danish Mole Project is a collaboration between Institute of Biomedicine, Aarhus University, Beijing Genomics Institute, ShenZhen, China and departments of clinical genetics, gynaecology, pathology, and oncology in the western part of Denmark.

Contact:

Lone Sunde, MD, PhD, Consultant, Assoc. Prof.

Tel: +45 7845 5520, Mobile: +45 4014 4364,

E-mail: lonsunde@rm.dk