(in cooperation with CFIN).
Magnetic resonance imaging (MRI) has expanded the understanding of acute ischemic stroke pathophysiology, especially by providing precise information on localization and extent of neuronal damage in the hyperacute phase following vascular occlusion. MRI is increasingly used in acute stroke, but the role of MRI in the selection of patients amenable for acute therapies has not been established into common guidelines.
CFIN researchers have developed methods that allow rapid assessment of blood flow disturbances by magnetic resonance techniques. These methods are now widely used in neuroscience and are gaining increased attention as a tool for improved clinical management of acute stroke patients.
Challenged by the need to translate basic research and sophisticated methods into better patient management, the Departments of Neurology and Neuroradiology utilized these discoveries in introducing MR guided thrombolytic treatment to stroke patients admitted to Aarhus University Hospital, within 3 hours of symptom onset. While CFIN scientists developed software to allow the use of CFIN perfusion methods in time critical stroke management, MD, PhD students took part in acute patient management while collecting data for their basic stroke and neuroscience related research.
There are currently several studies on-going in collaboration between the Dept. of Neurology, Center of Functionally Integrative Neuroscience (Aarhus University), Dept. of Clinical Epidemiology, and Neuroradiology:
- Is there an effect of anti-depressant medication on final infarct size?
- Investigation of imaging and clinical predictors on post-stroke prognosis
- Does treatment with theophylline influence final infarct size?
We are furthermore part of multicenter studies evaluating new thrombolytic agents and delayed treatment of patients waking up with stroke symptoms.