PhD-student: Tor Skibsted Clemmensen (Dept. of Cardiology)
Dept. of Nuclear Medicine & PET Centre: Lars Poulsen Tolbod, Hendrik Johannes Harms, Kirsten Bouchelouche, Jens Sørensen, Jørgen Frøkiær
Background: Amyloidosis is a rare systemic disorder characterized by extracellular deposition of misfolded proteins in various organ systems, including the heart. In the heart, cardiac amyloidosis (CA) leads to extracellular deposits resulting in increased biventricular wall thickness and stiffness, subsequently leading to heart failure.
Objectives: To evaluate the impact of reduced coronary flow velocity reserve CFVR in CA patients on systolic and diastolic myocardial function, efficiency (measured by 11C-acetate PET) and hemodynamics at rest and during exercise, and to optimize methods for diagnosis of cardiac amyloid deposits (incl. 11C-PIB PET).