RESIST trial:Remote ischemic conditioning in patients with acute stroke: a multicenter randomized controlled study, open label and blinded end-point study, examining the effect on disability

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PhD study

PhD student: Rolf Ankerlund Blauenfeldt Department of neurology, AUH

Main supervisor: Professor Grethe Andersen

Co-supervisors: Associate Professor Niels Hjort, Department of Neurology, Aarhus University Hospital, Professor Hans Kirkegaard, Emergency Department and Associate Professor Søren Paaske Johnsen, Department of Clinical Epidemiology, Aarhus University Hospital.

Purpose: An investigator-driven, multicentre, prospective, randomised, single blinded with blinded end-point trial of perconditioning treatment during ambulance transport to hospital in patients with suspected acute stroke. Perconditioning is a promising method with no known adverse effects. It has shown neuroprotective effects and may save ischemic brain tissue from infarction. The aim is to include 2300 patients in collaboration with the prehospital services.

Study period: 01 Sept 2017-30 Aug 2023
Funding: Fabrikant Vilhelm Pedersen and hustru mindelegat (DKK 1.24 mio) and TrygFonden (DKK 4 mio.)