Basic biomedical reesearch focuses primarily on aspects of HIV replication and pathogenesis. Dr. Trine Mogensen studies mechanisms of innate immune recognition of HIV in both monocytes/macrophages as well as T cells. Martin Tolstrup is primarily studying the mechanisms of HIV latency and how to define the latently infected cell in order to manipulate the cell to display HIV antigens to allow immune recognition.
In addition, many of the technologies developed/implemented function as facilitators for analysis of effects from clinical interventional or cross-sectional studies with great emphasis on immune cell description by multi-color flow cytometry.
Contacts:
Trine Mogensen, MD, DMSc, PhD, trinmoge@rm.dk
Martin Tolstrup, MSc, PhD, martol@rm.dk
Collaborators:
Professor Søren Paludan, Dept of Biomedicine, Aarhus University
Professor Sharon Lewin, Burnet Institute, Melbourne
Ass Professor Mathias Lichterfeld, Mass Genereal Hospital, Boston
Ass Professor Sarah Palmer, Karolinska Institute, Stockholm
Professor Finn Skou Pedersen, Institute of Molecular Biology, Aarhus University
Professor Charles Dinarello, University of Colorado, Denver