Clostridium Difficile infection and faecal microbiota transplantation 

The aims are to investigate

  • associations between increasing age and frailty in a Danish population of older patients with Clostridium Difficile Infection (CDI)
  • risk factors for CDI recurrence and mortality in a Danish population of patients with CDI aged 75+ years
  • whether an early, multi-disciplinary geriatric tailored intervention, including geriatric assessment of the indication for faecal microbiota transplantation (FMT) and follow-up in a cooperation with the primary sector, is able to improve survival as compared to standard care in patients aged 75+ years

Contact: Tone Rubak

Collaborator: Department of Hepatology and Gastroenterology

Publication: Jørgensen SMD, Rubak TMM, Damsgaard EM, Dahlerup JF, Hvas CL. Faecal microbiota transplantation as a home therapy to frail older people. Age and Ageing 2020;49(6);1093-96

Clinical presentation and outcomes of COVID-19 in older hospitalised patients

We aimed to describe the clinical presentations of COVID-19 in older inpatients with regard to frailty measured by the record-based Multidimensional Prognostic Index (rMPI) tool and to explore possible associations between frailty level and decision of treatment level, change in physical functional abilities and survival. Subsequently, the predictive values of rMPI and Clinical Frailty Scale were compared.

Contact: Lone Winther Lietzen

Publication: Verholt AB, Gregersen M, Gonzalez-Bofill N, Hansen TK, Ebdrup L, Foss CH, Lietzen LW. Clinical presentation and outcomes of COVID-19 in older hospitalised patients assessed by the record-based Multidimensional Prognostic Index, a cross-sectional study. European Geriatric Medicine. 2021 https://doi.org/10.1007/s41999-021-00522-3

Source- and social isolation experienced by older hospitalised patients with COVID-19 and their relatives - a qualitative study

We aim to explore how older patients with COVID-19 and their relatives experience the separation during hospitalization to identify important themes to refine the guidelines concerning isolation.

Contact: Merete Gregersen

Collaborator: Department of Infectious Diseases

Hospital-acquired infections in single-bed versus multi-bed rooms

We aimed to examine if hospitalisation in single-bed rooms reduces the number of HAIs compared to multi-bed rooms in older patients admitted to geriatric wards.

Contact: Merete Gregersen

Publication: Gregersen M, Mellemkjær A, Foss A-CH, Blandfort S. Use of single-bed rooms may decrease the incidence of hospital-acquired infections in geriatric patients: A retrospective cohort study in Central Denmark region. Journal of Health Services Research & Policy. 2021 https://doi.org/10.1177/1355819621994866