Region Midtjyllands logo.

Aarhus University Hospital

Hop til hovedindhold
Danish
Frontpage
  • Research

  • Innovation

  • Jobs and Careers

  • About the Hospital

  • Departments

  • Research
  • Innovation
  • Jobs and Careers
  • About the Hospital
  • Departments
  • News
  • Cookies
Departments Department of Nuclear Medicine & PET-Centre Research areas

Research areas

Go to

Print

Contact

Related pages

Useful links

Departments
  • Department of Nuclear Medicine & PET-Centre
  • Research areas

Research areas

Cardiovascular

Metabolism

Nephro-urology

Neurology and Neuroscience

Preclinical

Tracer & Method development

This PhD-study investigates the distribution and burden of alpha-synuclein pathology in post-mortem human brains from patients with Parkinson’s disease (PD) and incidental Lewy body disease using immunohistochemical (IHC) methods. The post-mortem brains used in this study was collected in 1945-1982 and are part of the Danish Brain Collection (previously located in Risskov).

Neuropathological studies have shown a brainstem-predominant pattern of alpha-synuclein pathology and a limbic system-predominant pattern. Brains from the Danish Brain Collection have both hemispheres conserved in a fixative making it possible to perform bilateral IHC analyses.

We aim to explore the symmetry/asymmetry aspect of PD by investigating the alpha-synuclein distribution bilaterally.

Here, we hypothesize that brainstem-predominant cases will show a symmetrical spreading pattern representing PD cases, where pathology originates in the autonomic nervous system, whereas limbic system-predominant cases will show an asymmetrical spreading pattern representing PD cases, where pathology originates within the brain in a single site, i.e. unilaterally.

 

Mie2.jpg










Contact Mie Just, PhD student

Main supervisor: Per Borghammer,  PhD, Clinical Professor

Contact

About the Department

Staff

Aarhus University Hospital

Palle Juul-Jensens Boulevard 99
DK-8200 Aarhus N
+45 7845 0000
auhhov@rm.dk

Contact us

Executive Management

International affairs

Development Office

Media Contact

Departments

  • Cookies
  • Availiability statement (in Danish)